A Comparator Study Evaluating Microbiological Resistance and Effects of Alternating Inhaled Antibiotic Therapies
Completed
Conditions studied: Cystic Fibrosis, Pseudomonas Aeruginosa
In brief
This is a pilot study of inhaled antibiotic regimens is a pilot study examining clinical and laboratory endpoints of patients on inhaled antibiotic treatments. We hypothesize that alternation therapy utilizing Cayston and Tobi will inhibit antibiotic resistance and that alternation therapy will result in a decreased incidence of antibiotic resistance to Cystic Fibrosis (CF) microbial isolates. The long term strategic goal is to develop a model biometric system for selecting a patient's optimal inhaled antibiotic regimen by utilizing clinical and microbiological parameters.
Key facts
- Study ID
- NCT01319253
- Run by
- Indiana University
- People needed
- 27
- Starts
- 2011-03-01
- Expected to finish
- 2015-10-01
- Last updated by the study team
- 2015-11-06
Who can join
Age: 6 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- > or = to 6 years of age
- Documentation of Cf diagnosis
- History of PA present in sputum, on a least one occasion, during the 12 months prior to Visit 1.
- Currently on inhaled antibiotic regiment
- Must be able to provide written informed consent or assent prior to any study related procedures
- Ability to expectorate sputum
- Ability ro perform reproducible pulmonary function test
You may not qualify if…
- Administration of any IV or oral antipseudomonal antibiotic within 28 days prior to Visit 1
- Any serious or active medical or psychiatric illness, which in the opinion of the investigator, woud interfere with participant treatment, assessment, or compliance with the protocol
- Current enrollment in an interventional clinical trial
Where it is running
- Indiana University — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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