Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Starting soon

Conditions studied: Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure

In brief

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Key facts

Study ID

NCT01315782

Run by

The University of Texas Health Science Center, Houston

People needed

30

Starts

2026-12-01

Expected to finish

2026-12-01

Last updated by the study team

2025-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults with severe sepsis or septic shock on mechanical ventilation
• Enrolled in the initial six hours of ICU admission

You may not qualify if…

• Patients with withdrawal or hospice order.
• Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
• Patients with COPD.
• Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Where it is running

• Memorial Hermann Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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