Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation
Completed · Not applicable
Conditions studied: Cystic Fibrosis
In brief
The purpose of this study to investigate the effect of sulforaphane from macerated broccoli sprouts in humans and to evaluate less invasive methods of assessing potential anti-inflammatory drugs in CF.
Key facts
- Study ID
- NCT01315665
- Run by
- University Hospitals Cleveland Medical Center
- People needed
- 15
- Starts
- 2011-04-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2019-02-15
Who can join
Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteers and patients with cystic fibrosis ≥ 18 < 50 years of age
- Healthy volunteers must be in general good health as determined by a medical history
- CF subjects must have a documented diagnosis of CF (positive sweat chloride ≥ 60 mEq/liter, by pilocarpine iontophoresis) and/or a genotype with two identifiable mutations consistent with CF accompanied by one or more clinical features with the CF) phenotype
- CF subjects must have a baseline FEV1 percent predicted > 50% (in the last year, obtained from medical record)
- CF subjects must be clinically stable: free of any acute illness for > 14 days CF subjects must not have been prescribed any new systemic antibiotics for the 14 days prior to enrollment
- Ability to provide written informed consent
- Ability to adhere to the protocol
You may not qualify if…
- Use of NSAIDS (e.g., ibuprofen) or corticosteroids including inhaled steroids for the 4 weeks prior to enrollment
- Active gingival disease (active tooth or gum disease)
- History of nephrolithiasis or cholelithiasis
- Allergy to broccoli
- Any chronic condition that compromises the participant as determined by medical history
- Pregnancy
- Inability to tolerate the study procedures
- CF subjects: Infected with B. cepacia
Where it is running
- Rainbow Babies and Children's Hospital — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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