Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

Completed · Not applicable · Has a placebo group

Conditions studied: Schizophrenia

In brief

Individuals with schizophrenia have been found to have deficits in social cognition, which is defined as the functions that are engaged during social interactions. Social cognition has been found to be critical in predicting multiple aspects of community functioning. There are no currently available medications that have been consistently found to improve social cognition in individuals with schizophrenia. Oxytocin functions as a neurotransmitter that is thought to be involved in multiple aspects of social behavior and related emotions. In this study, we test the hypothesis that acute administration of intranasal oxytocin will improve social cognition in individuals with schizophrenia.

Key facts

Study ID

NCT01312272

Run by

VA Greater Los Angeles Healthcare System

People needed

24

Starts

2011-04-01

Expected to finish

2012-08-01

Last updated by the study team

2014-05-02

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Veteran being treated in the Veterans Administration Healthcare System
• Meet DSM-IV-TR criteria for Schizophrenia
• At least 6 months since any hospitalization or substantial increase in level of care for an acute exacerbation of psychotic symptoms
• At least 1 month since meeting the criteria for having a major depressive episode
• At least 6 months since any behaviors suggesting any potential danger to self or others
• Adherence to the regular administration of an antipsychotic medication (e.g., risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, paliperidone, iloperidone, asenapine, fluphenazine, haloperidol, loxapine, molindone, perphenazine, thiothixene, chlorpromazine, clozapine)
• Dose of antipsychotic medication not varying by more than 25% over the 3 months prior to study participation
• No acute medical problems
• Chronic medical conditions (e.g., hypertension, diabetes, dyslipidemia) consistently treated and stable for at least 3 months prior to study participation
• Ability to provide signed informed consent and to cooperate with study procedures

You may not qualify if…

• Documented history of mental retardation or severe learning disability
• History of treatment with electroconvulsive therapy within 6 months prior to study participation
• History of neurological or neuropsychiatric condition (e.g., stroke, severe traumatic brain injury, epilepsy, etc.)
• Documented history of persistent substance abuse or dependence within 6 months prior to study participation
• History of hyponatremia within the past 6 months
• Allergic rhinitis or other inflammation of the nasal mucosa

Where it is running

• West Los Angeles VA Healthcare Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.