Initiation of Allopurinol at First Medical Contact for Acute Attacks of Gout

Completed · Phase 4 · Has a placebo group

Conditions studied: Gout, Gout Acute

In brief

Medical teaching suggests allopurinol should not be initiated in the setting of an acute attack of gout, as rapid lowering of serum urate may exacerbate the attack. This study tests the hypothesis that there is no difference in patient reported daily pain or flair occurrences with early versus delayed institution of allopurinol during an acute gout attack.

Key facts

Study ID

NCT01310673

Run by

White River Junction Veterans Affairs Medical Center

People needed

57

Starts

1998-01-01

Expected to finish

2009-07-01

Last updated by the study team

2011-03-08

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• First medical contact for acute attack of gout.
• ACR criteria for acute attack of gout
• Crystal proven by arthrocentesis on day of enrollment
• Primary gout

You may not qualify if…

• Secondary Gout
• Tophaceous Gout
• Prior steroid, colchicine, or uric acid lowering therapy in the past 6 months.
• Uncontrolled CHF
• Unstable angina
• Renal insufficiency (entry CREAT > 1.3)
• Anticoagulant therapy
• Immunosuppressive therapy or chemotherapy in the past 6 months
• Pregnancy; OR
• Known allergy to NSAID, colchicine, or allopurinol

Where it is running

• White River Junction VA Medical Center — White River Junction, Vermont, United States

Full record on ClinicalTrials.gov

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