Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic Features

Stopped early

Conditions studied: Major Depressive Disorder, Major Depressive Disorder w/ Psychotic Features, Metabolic Syndrome

In brief

Studies have shown that people with certain disorders have an increased risk of developing a condition called Metabolic Syndrome (MS). In this study, the investigators want to learn more about MS among people staying in the hospital for treatment of Major Depressive Disorder (MDD) and also Major Depressive Disorder with Psychotic Features (MDpsy). The investigators also want to learn more about a stress hormone called cortisol that is made in the body. Those who take part in this study will answer some questionnaires, be given some psychiatric interviews, and have some blood taken along with a urine sample. The investigators believe that patients in the hospital with MDpsy will have higher baseline rates of MS factors, cortisol levels, dexamethasone non-suppression, and insulin resistance, compared with MDD alone.

Key facts

Study ID

NCT01310140

Run by

Massachusetts General Hospital

People needed

14

Starts

2011-01-01

Expected to finish

2012-09-01

Last updated by the study team

2017-02-13

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Capable of giving informed consent
• DSM-IV TR diagnosis of Major Depressive Disorder with (MDpsy) or without (MDD) Psychotic Features
• Age between 18 and 85, inclusive
• Pre-existing Hyperlipidemia, Hypertension, and Diabetes must be stable with laboratory and clinical results within acceptable range; with or without medication for three months prior to admission

You may not qualify if…

• DSM-IV TR diagnosis of: schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder, organic mental disorder, substance use dependence including alcohol, that has been active within the past 6 months, acute bereavement, and psychotic disorder not elsewhere classified
• Subjects that meet criteria for substance or alcohol dependence more recently than three months prior to entering the study
• Subjects that meet criteria for substance or alcohol abuse more recently than four weeks prior to entering the study
• Pregnancy
• Unstable or inadequately treated pre-existing hyperlipidemia, hypertension, and diabetes
• Subjects who are involuntarily committed.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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