Hemodynamic Optimization By Non-Invasive Determination Of Cardiac Output In Critically Ill Patients
Completed · Not applicable
Conditions studied: Hypotension
In brief
Inadequate identification of and subsequent delayed therapy for patients with hypoperfusion (including hypovolemia, congestive heart failure and sepsis) is a common problem faced by physicians and intensivists caring for critically ill patients. Bedside clinical assessment is notoriously inaccurate in diagnosing complex etiologies of hemodynamic disturbances and in deciding on the appropriate therapy. Invasive techniques which are often required to guide diagnosis and therapy have significant risks associated with them, are costly, and are time consuming. New technology has been developed that allows for instantaneous, noninvasive monitoring of key hemodynamic parameters, like stroke volume, peak velocity and cardiac output. This new technology has the potential to improve recognition of the etiology of hemodynamic disturbances and assist the clinician in optimizing therapy based on changes in hemodynamic parameters. There is significant potential for this to be translated into improved outcomes in critically ill patients, but this has never been studied.
Key facts
- Study ID
- NCT01309724
- Run by
- Washington University School of Medicine
- People needed
- 92
- Starts
- 2010-01-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2011-03-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 yrs or greater
- Administration of vasopressors, defined as a continuous infusion of norepinephrine at a dose >5 mcg/min, dopamine ≥5 mcg/kg/min or any dose of another vasopressor
- Passage of <18 hours since initiation of vasopressors at doses specified above
You may not qualify if…
- Hemorrhagic shock
- Need for immediate surgery
- Imminent risk of death in the next 48 hours (as judged by the attending ICU physician)
- Level of care decision that precluded implementation of the study protocol
- Enrollment in any other clinical study
- Pregnancy
Where it is running
- Barnes-Jewish Hospital — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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