Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
Stopped early · Not applicable
Conditions studied: Major Depression, Bipolar Depression
In brief
The primary objectives of this study are to investigate the potential for ketamine anesthesia to increase the antidepressant efficacy of Electroconvulsive therapy (ECT) and to decrease acute ECT-induced adverse cognitive effects.
Key facts
- Study ID
- NCT01309581
- Run by
- James Murrough
- People needed
- 3
- Starts
- 2010-04-01
- Expected to finish
- 2010-10-01
- Last updated by the study team
- 2013-08-30
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients: 18 to 59 years
- Women of childbearing potential must agree to use a medically accepted means of contraception for the duration of the study
- DSM IV MINI diagnosis of major depressive episode (MDD), unipolar or bipolar
- Pretreatment 24-item Hamilton Rating Scale for Depression score > 21
- ECT is clinically indicated
- Patient has the capacity to provide informed consent.
You may not qualify if…
- DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or mental retardation
- Current primary diagnosis of anxiety disorder, obsessive- compulsive disorder, or eating disorder that precedes the onset of the current episode of depression
- Current diagnosis of delirium, dementia, or amnestic disorder
- Baseline Mini Mental State Exam (MMSE) score < 24 and a total score falling two standard deviations below the age- and education-adjusted mean
- Any active general medical condition or CNS disease which can affect cognition or response to treatment
- Current (within the past three months) diagnosis of active substance dependence, or active substance abuse within the past week
- Lifetime history of ketamine or PCP abuse or dependence
- ECT within three months
- The presence of any known or suspected contraindication to methohexital or ketamine including but not limited to known allergic reactions to these agents, uncontrolled hypertension arrhythmia severe coronary artery disease and porphyria
- Pregnancy
Where it is running
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
Full record on ClinicalTrials.gov
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