Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension

Status unconfirmed · Phase 4

Conditions studied: Prehypertension

In brief

Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.

Key facts

Study ID

NCT01308983

Run by

Augusta University

People needed

32

Starts

2010-09-01

Last updated by the study team

2012-10-23

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration.
• Male or female of Caucasian or African-American origin.
• No history of any major past and current medical illness (such as diabetes, renal disease, liver disease etc.)
• Not taking any medication that affects blood pressure.

You may not qualify if…

• HbA1C > 7.0 % during screening visit.
• Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of developing hyperkalemia.
• Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction.
• Female having positive pregnancy test during screening and/or any testing visit.

Where it is running

• Georgia Prevention Institute — Augusta, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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