The Effect of Birth Control Methods on Anti-Mullerian Hormone (AMH) Levels

Withdrawn before enrolling

Conditions studied: Birth Control

In brief

Anti-mullerian hormone (AMH) has been shown to be a reliable marker of ovarian reserve. In prior studies, tubal ligation has been shown to have an adverse effect on ovarian reserve. One theory postulated for this effect is that the ovarian circulation is disrupted by the procedure, leading to altered hormone production. In this prospective cohort study, the investigators plan to analyze the rates of AMH decline by comparing the following contraceptive methods: tubal ligation, Essure placement, and levonorgestrel intrauterine devices (IUDs).

Key facts

Study ID

NCT01308931

Run by

Valleywise Health

People needed

0

Starts

2013-01-01

Expected to finish

2015-01-01

Last updated by the study team

2014-08-05

Who can join

Age: 25 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• English-speaking
• Female
• Age 25-40
• Electing one of the following contraceptive methods: tubal ligation, Essure, levonorgestrel IUD
• Ability to understand study procedures and to comply with them for the entire length of the study
• Willingness to comply with follow-up visit requirements

You may not qualify if…

• Age <25 or >40 at initiation or completion of the study
• Prior oophorectomy or salpingectomy
• Prior surgery of the ovaries or fallopian tubes
• Prior ovarian, uterine, or fallopian tube cancers
• Prior ovarian, uterine, or fallopian tube radiation exceeding >200rads
• Prior platinum-based or alkalizing chemotherapy
• Current cancer (any form)
• Current pregnancy
• Allergy to any of the components of the selected devices (titanium, rubber, nickel, plastic, silicone)
• Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements
• Inability or unwillingness of a potential participant to give written informed consent
• Inability for the potential participant to consent for herself

Where it is running

• Maricopa Integrated Health System — Phoenix, Arizona, United States
• St Joseph's Hospital & Medical Center — Phoenix, Arizona, United States
• Fertility Centers of Arizona — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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