Monitor Response to Treatment in Neuroblastoma Using 3&Apos;-Deoxy-3&Apos;-Fluorothymidine- Positron Emission Tomography (FLT-PET)

Status unconfirmed · Not applicable

Conditions studied: Neuroblastoma

In brief

The purpose of this study is to gain knowledge about how to best diagnose and treat tumors, how tumors affect normal tissue and how treatment of tumors with radiation therapy and chemotherapy affect tumors.

Key facts

Study ID

NCT01308905

Run by

Barbara Ann Karmanos Cancer Institute

People needed

50

Starts

2011-02-01

Expected to finish

2018-02-01

Last updated by the study team

2017-04-06

Who can join

Age: 0 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients with neuroblastoma or suspected neuroblastoma seen at Children's Hospital of Michigan (CHM). Patients need to be 2 years or older to be eligible for the initial study
• Patients must be 1 day to 21 years old, there is no gender limit.
• Diagnosis: All patients with neuroblastoma or suspected neuroblastoma, including newly diagnosed and relapsed patients, are eligible for Objective 1. To be eligible for Objective 2, patients must have a diagnosis of neuroblastoma verified by histology or demonstration of clumps of tumor cells in bone marrow with elevated urinary catecholamine metabolites, and have measurable disease after the initial surgery
• Female adolescent patients must have a negative pregnancy test within 14 days of first imaging and should not be pregnant
• Patients must be able to lie still for the tests, or have no contraindication for sedation
• Patients or their legal guardian must sign an informed consent indicating that they are aware of the investigational nature of this study
• A total number of 40-50 patients will be included in the study

You may not qualify if…

• Patients who do not have a histology diagnosis of neuroblastoma are not eligible for the study
• Patients whose definite diagnosis after surgery is not consistent with the diagnosis of neuroblastoma will be included in the Objective 1 but excluded for Objective 2.

Where it is running

• Children's Hospital of Michigan — Detroit, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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