Noninvasive Evaluation of Cardiac Allograft Vasculopathy

Withdrawn before enrolling

Conditions studied: Cardiac Allograft Vasculopathy

In brief

Abnormal peripheral endothelial function and alterations in circulating biomarkers that are associated with endothelial activation and inflammation correlate with angiographic evidence of cardiac allograft vasculopathy, defined as greater than 25% stenosis in a major coronary artery.

Key facts

Study ID

NCT01305382

Run by

University of Minnesota

People needed

0

Starts

2008-10-01

Expected to finish

2013-12-01

Last updated by the study team

2016-11-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18 years
• Provide informed consent
• Presence of advanced heart failure (NYHA class III, IV) on medical therapy
• Patients with advanced heart failure on transplant list
• Transplant recipients undergoing invasive evaluation for coronary artery disease within 6 months to ten years post transplantation

You may not qualify if…

• Current tobacco use
• History of chronic kidney disease
• Active infection
• History of organ transplantation
• Diabetes Mellitus
• History of Hypertension
• Known coronary artery disease
• Connective tissue disorder
• History of hyperlipidemia
• History of Migraine or Chronic unevaluated headaches
• Patients with chronic kidney disease stage 4 defined as GFR<30 mL/min/1.73 m2 or acute renal failure
• Patients with acute rejection, Grade 3A or greater
• Active infection
• Re-transplant or Multi-organ transplant recipient
• Surgery within 3 months prior to enrollment

Where it is running

• Cardiology Division, University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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