Calcium Absorption in Patients With Rothmund-Thomson Syndrome

Completed · Not applicable

Conditions studied: Rothmund-Thomson Syndrome

In brief

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Because cure rates for osteosarcoma have remained stagnant for the past several decades despite numerous trials of chemotherapy agents, novel therapies based on the understanding of the molecular pathogenesis of osteosarcoma are needed. Rothmund-Thomson Syndrome (RTS) is a genetic disorder affecting many parts of the body and resulting in major skeletal abnormalities. This disease also has the propensity to increase the risk of developing cancer, particularly osteosarcoma. Two-thirds of RTS patients have a high risk of developing osteosarcoma. Therefore, it is important to understand the impact of RTS on the skeletal phenotype (as measured by bone density) in order to develop effective therapies to battle osteosarcoma.

Key facts

Study ID

NCT01304407

Run by

Baylor College of Medicine

People needed

29

Starts

2011-03-01

Expected to finish

2017-02-01

Last updated by the study team

2020-07-23

Who can join

Age: 4 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients at least four years of age who have been diagnosed clinically with RTS by a physician.

You may not qualify if…

• Any person who does not meet the inclusion criteria.

Where it is running

• Baylor College of Medicine / Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.