Does Glaucoma Cause Loss of Brain Function?

Completed · Not applicable

Conditions studied: Glaucoma

In brief

The purpose of the study is to determine if glaucoma is associated with neurodegenerative changes in areas of the brain other than the occipital lobe. This will help guide the direction of further research in the use of neuroprotective agents in preventing or controlling such changes. The final goal is to improve the quality of life for patients with glaucoma.

Key facts

Study ID

NCT01303939

Run by

Wills Eye

People needed

37

Starts

2010-08-01

Expected to finish

2013-08-01

Last updated by the study team

2018-11-20

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with glaucoma who were participated in other studies Assessment of Ability Related to Vision (AARV) or Assessment of Disability Related to Vision (ADREV) and were found to be outliers in that they have poor performance-based measure scores (≤ 40) despite having midrange visual field scores (mean deviation of -6 to -20).
• Age-, gender- and race-matched controls who do not have glaucoma, and who do not have loss of vision for any reason other than cataract or refractive error.

You may not qualify if…

• Patients with any type of neurological disease.
• Patients with a cognitive deficit which would affect visual functioning, as revealed by score of less than 25 in the mini mental status examination.

Where it is running

• Wills Eye Institute, Glaucoma Service — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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