Clinical Assessment of Barley and Oat Phytochemicals
Completed · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
The goal of this placebo-controlled, 3-way crossover study is to determine the acute (24-h) bioavailability and pharmacokinetics of the major phytochemicals found whole barley and oats, as well as their effects on selected measures of antioxidation, inflammation, insulin sensitivity/glucose regulation, and vascular remodeling following challenge by an oral glucose tolerance test (OGTT).
Key facts
- Study ID
- NCT01303562
- Run by
- Tufts University
- People needed
- 13
- Starts
- 2010-09-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2013-05-27
Who can join
Age: 40 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and postmenopausal women
- BMI 27-35.9 kg/m2
You may not qualify if…
- Cigarette smoking and/or nicotine replacement use
- Individuals taking estrogen
- Use of cholesterol-lowering medications
- Use of blood pressure-lowering medications
- Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements)
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 95 mmHg
- Regular use of oral steroids
- Regular daily intake of ≥ 2 alcoholic drinks
- Infrequent or excessive number of regular bowel movements
- Illicit drug use
- Vegetarians
- No fish oil supplements (including cod liver oil) for one month prior to study admission
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
Where it is running
- Tufts Clinical and Translational Research Center — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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