Natural History of Amyloid Deposition in Adults With Down Syndrome
Completed
Conditions studied: Down Syndrome
In brief
The primary objective of this study is to assess the presence of amyloid in non-demented/functionally stable adults with DS as a function of age, dividing the sample into amyloid-positive and amyloid-negative groups. We will also obtain baseline cognitive measures across a range of areas that are often affected by AD.
Key facts
- Study ID
- NCT01303133
- Run by
- University of Pittsburgh
- People needed
- 81
- Starts
- 2009-08-01
- Expected to finish
- 2018-03-31
- Last updated by the study team
- 2019-01-09
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant IQ at least 47 (based upon Stanford-Binet V Abbrev. Test Battery)
- Participant at least 30 years of age
- DSDS score indicating participant is asymptomatic for AD
- Reliable caregiver who is capable of providing correct information about the participant's clinical symptoms and history
- Agreement of caregiver and clinician that participant is able to cooperate with the protocol tasks
- Participant has provided assent (or consent) and/or parent/caregiver has provided informed consent
You may not qualify if…
- Participant is non-verbal or has extremely limited language skills
- Score within the "symptomatic" range on the DSDS
- Any significant disease or unstable medical condition that could affect neuropsychological testing
- Any problems with vision or hearing that could affect neuropsychological testing
- Participants in whom MRI is contraindicated
- Claustrophobia or prior failed experiences of completing MRI scans or blood draws
- Participant is pregnant or breast feeding
- History or other evidence of severe illness or other condition that would make the participant, in the opinion of the investigator, unsuitable for the study?
Where it is running
- University of Pittsburgh and University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
- Waisman Center at the University of Wisconsin - Madison — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.