Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke

Running, not enrolling

Conditions studied: Stroke

In brief

Stroke, a leading cause of disability in the aging population, increases the risk for diabetes, subsequent stroke recurrence, and cardiovascular disease complications. The downsizing of private and federal health care resources, along with the anticipated increase in stroke rates as our population ages, mandate that alternative strategies be developed to reduce the public health burden of stroke. This pilot study may facilitate our knowledge of the timing of paretic leg muscle atrophy, fiber type shift, and the progression of worsening of glucose tolerance after stroke. Knowledge of the skeletal muscle changes occurring in the sub-acute stroke period is essential to create new guidelines incorporating exercise rehabilitation, much like cardiac rehabilitation, in order to facilitate and improve the health care of veteran stroke survivors.

Key facts

Study ID

NCT01302197

Run by

Baltimore VA Medical Center

People needed

100

Starts

2011-04-13

Expected to finish

2026-06-01

Last updated by the study team

2024-08-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men or women 21 years of age or older
• BMI between 20-50 kg/m2
• Presenting within a month after stroke onset with residual hemiparetic deficit
• Patients must have adequate language and neurocognitive function to participate in testing and give adequate informed consent

You may not qualify if…

• Patients deemed too disabled to participate in physical therapy, or patients with minimal deficits, or patients who fully recovered after their stroke, in which physical therapy is not necessary
• Unstable angina, CHF, severe PAD
• Dementia or untreated major depression
• Severe receptive or global aphasia
• Heavy alcohol use defined by greater than 3 oz. liquor, 12 oz of wine or 32 oz of beer daily
• Muscle biopsy Exclusion Criteria:
• anti-coagulation therapy with heparin, warfarin, or lovenox (anti-platelet therapy is permitted)
• bleeding disorder
• allergy to lidocaine

Where it is running

• University of Maryland Medical System — Baltimore, Maryland, United States
• VA Maryland Health Care System, Baltimore — Baltimore, Maryland, United States
• Kernan Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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