Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy

Completed

Conditions studied: Mitochondrial Disease

In brief

This is a developmental protocol to determine the MRI based 31P-MRS changes seen in subjects with mitochondrial myopathy using our dynamic exercise protocol and to identify the ideal variable(s) to represent mitochondrial function.

Key facts

Study ID

NCT01301235

Run by

Massachusetts General Hospital

People needed

8

Starts

2011-02-01

Expected to finish

2012-04-01

Last updated by the study team

2012-04-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women ≥ age 18 years old with primary mitochondrial myopathy
• Known alteration in electron transport chain activity (<25 % activity of ETC) or known mutations in mitochondrial gene.

You may not qualify if…

• Failure based on standard clinical MRI Screening form - the form is intended to establish the safety of subjects participating in the MRI scan without divulging any confidentiality information -

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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