Molecular Determinants of Acquired Clinical Resistance to Crizotinib in Non-small Cell Lung Cancer Harboring a Translocation or Inversion Event Involving the ALK Gene Locus
Completed
Conditions studied: Lung Cancer
In brief
The purpose of this study is to try to learn more about how small molecule kinase inhibitor medications work in treating lung cancer. Crizotinib (PF-02341066) is a drug that has been shown to shrink tumors in some patients with lung cancer. While the investigators know how this drug works to stop the growth of tumors that depend on change in the gene named ALK (also called EML4-ALK), the investigators do not know why the drug stops working. The investigators would like to examine the tumor to help us better understand why crizotinib has stopped working as well as it once did. The tumor will be examined with multiple tests to look for the reason that crizotinib stopped working.
Key facts
- Study ID
- NCT01300429
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 30
- Starts
- 2011-02-08
- Expected to finish
- 2021-01-05
- Last updated by the study team
- 2021-01-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥18 years of age
- Histologically proven diagnosis of NSCLC at MSKCC Tumor positive for a translocation or inversion event involving the ALK gene locus
- Clinical response to treatment with crizotinib as defined by either:
- Radiographic partial or complete response defined by RECIST or WHO
- OR:
- Radiographic stable disease for at least 8 weeks
- Radiographic progression of disease amenable to biopsy while on treatment with crizotinib as defined by RECIST or WHO
- Signed informed consent
You may not qualify if…
- Deemed by their treating physician to be medically unfit for biopsy
- Women who are pregnant or breast-feeding
Where it is running
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
Full record on ClinicalTrials.gov
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