Preventing Cognitive Decline in African Americans With Mild Cognitive Impairment
Completed · Phase 3
Conditions studied: Mild Cognitive Impairment (MCI)
In brief
The goal of this study is to determine whether increasing participation in cognitive, physical, and/or social activities prevents cognitive decline in older African Americans (AAs) with Mild Cognitive Impairment (MCI). Patients with MCI are at increased risk for Alzheimer's Disease (AD); we propose that increasing participation in activities will prevent cognitive decline and may delay the onset of Alzheimer's Disease (AD). We will test this hypothesis by conducting a clinical trial in which older AAs with MCI (aged 65 years and older) will be randomized to Behavior Activation (BA) (a behavioral intervention that increases participation in daily activities) or Supportive Therapy (ST) (a person-centered psychotherapy that involves active listening and offering support focusing on participants' problems and concerns). We hypothesize that BA-treated subjects will have fewer declines in cognitive and functional abilities, fewer depressive and neuropsychiatric symptoms, and better quality of life than ST-treated subjects at 24 months.
Key facts
- Study ID
- NCT01299766
- Run by
- Thomas Jefferson University
- People needed
- 221
- Starts
- 2011-06-21
- Expected to finish
- 2016-12-13
- Last updated by the study team
- 2018-12-12
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 65 years and older
- Having a friend/relative willing to serve as a Knowledgeable Informant (KI)
- Diagnosis of aMCI-MD
- Self-identified as African American
You may not qualify if…
- Psychiatric diagnosis, including dementia and major depression
- Sensory deficits that preclude neuropsychological testing
- Institutional residence
- Reduced life expectancy due to known terminal illness
Where it is running
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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