Progressive Weight Loss and Metabolic Health
Completed · Not applicable
Conditions studied: Insulin Resistance, Obesity
In brief
This study will evaluate the potential beneficial cardiometabolic effect of moderate (5%) weight loss and progressive (5%, 10%, and 15%) weight loss in obese adults without diabetes. Participants will be randomly assigned to one of 2 groups. Group 1: supervised weight loss group (low-calorie diet). Group 2: supervised weight maintenance group (normal diet). Of those assigned to group 1, half of the participants will lose 5% of their body weight and the other half will lose 5%, 10%, and 15% of their weight over time under the guidance of a dietitian. Research testing will be repeated at each time point (5%, 10%, and 15% weight loss). In group 2, research testing will be repeated after six months.
Key facts
- Study ID
- NCT01299519
- Run by
- Washington University School of Medicine
- People needed
- 59
- Starts
- 2011-02-01
- Expected to finish
- 2016-04-01
- Last updated by the study team
- 2017-07-05
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Obese: Body Mass Index from 30 to 45
- Insulin Resistant: HOMA-IR score greater than or equal to 2
You may not qualify if…
- diabetes
- smoking
- pregnancy
- breastfeeding
- heart failure
- history of liver disease including hepatitis
- alcoholism
- exercise more than 2 hours per week
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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