Acceleration and Relapse Prevention With Triiodothyronine (T3) as an Adjunct to Electroconvulsive Therapy (ECT)
Completed · Has a placebo group
Conditions studied: Depression
In brief
The purpose of this study is: * To evaluate liothyronine (Cytomel) as an accelerating agent (i.e. faster rate to clinical remission) to electroconvulsive therapy. * To evaluate whether thyroid supplement acceleration can reduce the neurocognitive side effect of ECT treatment. * To evaluate whether thyroid status at the time of remission is associated with subsequent relapse rate. * To evaluate genetic polymorphisms in enzymes responsible for thyroid metabolism and the serotonin transporter promoter gene in depression (5-HTTLRP).
Key facts
- Study ID
- NCT01299337
- Run by
- Mayo Clinic
- People needed
- 29
- Starts
- 2008-06-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2012-05-11
Who can join
Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 18-64, male and female, any race/ethnicity
- Current diagnosis of major depression (unipolar)
- Currently Hospitalized at Mayo Clinic Physician recommendation for ECT treatment at Mayo Clinic
- Willing to return to Mayo Clinic for follow-up
You may not qualify if…
- Inability to speak English
- Inability or unwillingness to provide written informed consent
- Psychotic depression (SCID-confirmed)
- Court-ordered involuntary ECT
- Currently receiving maintenance ECT
- Unstable current medical condition
- A condition that would deem triiodothyronine treatment unsafe
- Diagnosis of primary thyroid disorder
- Lithium treatment within 6 weeks of randomization
- Currently taking levothyroxine (Synthroid®) or triiodothyronine (Cytomel®)
- Subclinical hypo- or hyperthyroidism
- History of atrial fibrillation or any cardiac arrhythmia except sinus bradycardia
- History of myocardial infarction within the past 12 months or unstable coronary artery disease
- Pregnancy
- History of Osteoporosis
Where it is running
- Mayo Clinic Department of Psychiatry and Psychology — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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