Study of Acitretin to Treat Skin Rash Caused by Erlotinib (a Chemotherapy Drug)
Withdrawn before enrolling · Phase 4
Conditions studied: Skin Rash
In brief
This study will look at if a low-dose regimen of acitretin is helpful in treating a skin rash caused by the chemotherapy drug, erlotinib.
Key facts
- Study ID
- NCT01299220
- Run by
- University of Pittsburgh
- People needed
- 0
- Starts
- 2010-11-01
- Expected to finish
- 2011-09-01
- Last updated by the study team
- 2013-01-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age and older at the time of study enrollment.
- Started routine clinical, palliative, or experimental (off-label) treatment with erlotinib for solid tumors and have developed Grade 2 or higher skin toxicity based on National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.02.
- Failed therapy with a two-week course of antibiotic (doxycycline 100 mg twice daily, or cephalexin 250 mg twice daily in patients allergic to doxycycline).
- Willing and able to provide verbal and written informed consent
- If reproductive potential, both males and females,must practice effective contraceptive measures throughout the study. Women of childbearing potential must provide a negative pregnancy test (serum or urine) within 14 days prior to enrollment.
You may not qualify if…
- Pregnant or breast-feeding females.
- Known or suspected sensitivity to study medication.
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 3 or worse.
- Treatment with a non-approved or investigational drug (with the exception of erlotinib used in an experimental setting) within 30 days prior to Day 1 of study treatment.
- Prisoners or subjects who are compulsorily detained (involuntarily incarcerated)for treatment of either a psychiatric or physical (e.g., infectious) illness.
- Bilirubin greater than or equal to three times the upper limit of normal. Sexually active women of childbearing potential must use an effective method of birth
Where it is running
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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