Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas
Completed · Phase 1
Conditions studied: Pancreatic Cancer
In brief
RATIONALE: Monoclonal antibodies, such as ganitumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as gemcitabine hydrochloride and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Specialized radiation therapy, such as 3-dimensional conformal radiation therapy, that delivers a high-dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of ganitumab when given together with gemcitabine hydrochloride followed by radiation therapy, ganitumab, capecitabine, and maintenance therapy in treating patients with locally advanced cancer of the pancreas.
Key facts
- Study ID
- NCT01298401
- Run by
- Radiation Therapy Oncology Group
- People needed
- 8
- Starts
- 2012-02-01
- Expected to finish
- 2013-11-01
- Last updated by the study team
- 2015-11-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- St. Joseph Hospital Regional Cancer Center - Orange — Orange, California, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- James Graham Brown Cancer Center at University of Louisville — Louisville, Kentucky, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
- Summa Center for Cancer Care at Akron City Hospital — Akron, Ohio, United States
- McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center — Reading, Pennsylvania, United States
- Rhode Island Hospital Comprehensive Cancer Center — Providence, Rhode Island, United States
- Northmain Radiation Oncology — Providence, Rhode Island, United States
- M. D. Anderson Cancer Center at University of Texas — Houston, Texas, United States
Full record on ClinicalTrials.gov
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