Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Soft Tissue Sarcoma

Withdrawn before enrolling · Phase 1

Conditions studied: Soft Tissue Sarcoma

In brief

Ridaforolimus has been tested in almost 2 dozen studies; however, it has not previously been tested in combination with the standard of care chemotherapy for sarcoma as this study will. We will be looking to see if Ridaforolimus given with SOC chemo (AIM or TG) is well tolerated and to determine a Phase 2 dose.

Key facts

Study ID

NCT01296659

Run by

The University of Texas Health Science Center at San Antonio

People needed

0

Starts

2011-02-01

Expected to finish

2011-08-01

Last updated by the study team

2012-07-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced or metastatic soft tissue sarcoma with histological or cytological proven disease. No more than 2 lines of chemotherapy in the metastatic setting in the dose escalation phase, and no more than one line of prior therapy in the expansion phase.
• ECOG performance status of ≤ 1
• A minimum life expectancy > 3 months
• At least 4 weeks must have elapsed between prior investigational therapy, chemotherapy or radiotherapy and the first dose of ridaforolimus
• Adequate hematological, hepatic and renal function (hemoglobin ≥ 9g/dl, absolute neutrophil count [ANC] ≥ 1.5 x 109/L; platelets ≥ 100 x 109/L; bilirubin ≤ ULN; alkaline phosphatase ≤ 2.5 x ULN; AST, ALT ≤ 2.5 x ULN; albumin ≥ 2.5mg/dL; creatinine ≤ 1.5 x ULN)
• Serum cholesterol ≤ 350 mg/dL and triglycerides ≤400 mg/dL
• Signed informed consent
• Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to start of therapy and must use an approved contraceptive method as appropriate from the time of screening until 30 days after the last dose of study drug.

You may not qualify if…

• Uncontrolled brain metastases, spinal cord compression, or carcinomatous meningitis.
• Clinically significant unexplained bleeding within 28 days prior to entering the trial
• Uncontrolled systemic vascular hypertension
• Clinically significant cardiovascular disease
• Newly diagnosed (within 3 months of enrollment) or poorly controlled type 1 or 2 diabetes
• Have received >350 mg/m2 total dose of Doxorubicin
• Active infection requiring prescribed intervention
• Other concurrent illness
• Major surgery within 28 days before trial entry, or incompletely healed surgical incision; minor surgery or procedures within 7 days
• Previous anthracycline lifetime exposure more than 350 mg/m2 would exclude patient form AIM Arm enrollment
• Pregnant or breastfeeding
• Known allergy to macrolide antibiotics
• Concurrent treatment with medications that induce or inhibit cytochrome P450 (CYP3A).
• Known history of HIV sero-positivity

Where it is running

• Cancer Therapy & Research Center at UTHSCSA — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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