Cranberry Juice and Cardiovascular Disease

Completed · Not applicable · Has a placebo group

Conditions studied: Cardiovascular Disease

In brief

Previous studies have shown that consumption of a low calorie cranberry beverage imparts a favorable impact on HDL cholesterol, LDL oxidation, and cell adhesion molecules in men. However, these studies were not well controlled. Thus, it is important to confirm these effects in a blinded, placebo-controlled feeding study. The investigators goal is to verify the cardioprotective effects of cranberries by conducting a dietary intervention trial with healthy subjects in a controlled environment.

Key facts

Study ID

NCT01295684

Run by

United States Department of Agriculture (USDA)

People needed

60

Starts

2010-09-01

Expected to finish

2010-12-01

Last updated by the study team

2011-02-14

Who can join

Age: 25 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 25 to 65 years of age
• BMI 20 to 38 kg/m2

You may not qualify if…

• history of bariatric or certain other surgeries related to weight control
• kidney disease, liver disease, certain cancers, gout, hyperthyroidism, untreated or unstable hypothyroidism, gastrointestinal disease, pancreatic disease, other metabolic diseases, or malabsorption syndromes
• Type 2 diabetes or use of glucose-lowering medication
• Have a fasting blood sugar greater than 126 mg/dL
• LDL-cholesterol less than 130 mg/dL
• fasting triglycerides greater than 300 mg/dL
• use of cholesterol-lowering medication or supplements
• use of blood pressure-lowering medication
• smoking or use of other tobacco products (within 6 months prior to the start of the study)
• unwillingness to abstain from vitamin, mineral, and herbal supplements for 2 weeks prior to the study and during the study
• use antibiotics during the study,or for 3 weeks prior to starting the study.
• history of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
• weight loss of >/= 10% of your body weight within the last 12 months or plan to initiate a weight loss program during the next 10 months
• inability to eat cranberries
• inability or unwillingness to give informed consent or communicate with study staff
• self-reported history of alcohol or substance abuse within the past 12 months and/or are currently in treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
• other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol

Where it is running

• USDA's Beltsville Human Nutrition Research Center — Beltsville, Maryland, United States

Full record on ClinicalTrials.gov

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