Cancer Screening Program for Women at High Risk for Developing Ovarian Cancer
Stopped early · Early Phase 1
Conditions studied: Ovarian Diseases, Ovarian Neoplasms
In brief
The main purpose of this program is to see whether periodically measuring CA-125 (tumor marker) levels in the blood and undergoing transvaginal ultrasounds over time will be effective in the early detection of ovarian cancer.
Key facts
- Study ID
- NCT01292733
- Run by
- Swedish Medical Center
- People needed
- 534
- Starts
- 2009-08-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-01-20
Who can join
Age: 30 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Must meet one of the following:
- The family contains at least two ovarian or breast cancers in the subject or first or second degree relatives of the subject.
- The subject is of Ashkenazi Jewish ethnicity with one first degree or two second-degree relatives with breast or ovarian cancer, or subject is of Ashkenazi ancestry and has had breast cancer.
- The subject has a male relative with breast cancer diagnosed at any age.
- Probability of carrying a BRCA1/2 mutation given family pedigree of breast and ovarian cancers exceeds 20% (as determined by BRCAPRO 95% posterior probability interval).
You may not qualify if…
- Prior ovarian cancer or peritoneal carcinomatosis
- A first or second degree relative with a BRCA1/2 mutation and has tested negative for exactly the same mutation.
- The subject has no ovaries.
- Less than 30 years of age, unless 25-30 with BRCA I or II mutation confirmed
- Currently pregnant
- Currently receiving adjuvant chemotherapy or radiation therapy for cancer (excluding tamoxifen). Patients who are being treated for local disease may enroll 3 months after completion of last treatment (excluding tamoxifen).
- Treatment (excluding tamoxifen) for prior metastatic malignancy within the past five years.
- Intraperitoneal surgery within the last 3 months.
Where it is running
- Marsha Rivkin Center for Ovarian Cancer Research — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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