Study to Evaluate the Safety and Tolerability of IV Doses of BMS-906024 in Subjects With Advanced or Metastatic Solid Tumors
Completed · Phase 1
Conditions studied: Cancer
In brief
The purpose of this study is to identify a safe and tolerable dose of BMS-906024 in subjects with advanced or metastatic solid tumors who no longer respond to or have relapsed from standard therapies.
Key facts
- Study ID
- NCT01292655
- Run by
- Bristol-Myers Squibb
- People needed
- 94
- Starts
- 2011-03-03
- Expected to finish
- 2017-06-22
- Last updated by the study team
- 2020-01-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects with advanced or metastatic solid tumors (non-hematologic refractory to or relapsed from standard therapies or for which there is no known effective treatment during dose escalation
- Subjects with squamous non-small cell lung cancer and triple-negative breast cancer or other solid tumor types for which Notch activation has been demonstrated (such as pancreatic, ovarian and melanoma) during dose expansion
- Biopsy accessible tumor (may be waived under certain circumstances)
- Life expectancy of at least 3 months
- Eastern Cooperative Oncology Group (ECOG) 0-1
- Adequate organ and bone marrow function
You may not qualify if…
- Infection
- Elevated triglycerides
- Gastrointestinal (GI) disease with increased risk of diarrhea [e.g. inflammatory bowel disease (IBD)]
- Taking medications known to increase risk of Torsades De Pointes
Where it is running
- Anthony El-Khoueiry, Md — Los Angeles, California, United States
- Winship Cancer Institute. — Atlanta, Georgia, United States
- Wayne State University — Detroit, Michigan, United States
- University Of Mississippi Medical Center — Jackson, Mississippi, United States
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
- The Methodist Hospital Research Institute — Houston, Texas, United States
- Local Institution — Parkville, Victoria, Australia
- Local Institution — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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