Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia

Completed · Phase 1/Phase 2

Conditions studied: Schizophrenia, Schizoaffective Disorder

In brief

This study will integrate and adapt a cognitive remediation (Cognitive Enhancement Therapy \[CET\]) and an affect regulation (Personal Therapy \[PT\]) intervention for 50 individuals with schizophrenia that misuse cannabis. Participants will be randomized to CET/PT plus treatment as usual (TAU) or TAU alone and treated for 18 months.

Key facts

Study ID

NCT01292577

Run by

University of Pittsburgh

People needed

33

Starts

2010-09-01

Expected to finish

2014-09-01

Last updated by the study team

2020-04-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of schizophrenia or schizoaffective disorder confirmed by the Structured Clinical Interview for DSM-IV Disorders (SCID).
• Cannabis severity scores of moderate or higher on the Addiction Severity Index (ASI).
• present with significant cognitive disability based on the Cognitive Style and Social Cognition Eligibility Interview
• Intelligence quotient (IQ) greater than 80
• Ability to read and speak fluent English
• Ability to attend weekly treatment sessions in Pittsburgh, PA.

You may not qualify if…

• Organic Brain Syndrome
• English Language below a sixth grade level
• Persistent suicidal or homicidal behavior
• comorbid medical disorders producing cognitive impairment
• receipt of substance abuse pharmacotherapies (e.g., naltrexone)

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.