Pentoxifylline Treatment of Acute Pancreatitis

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Acute Pancreatitis

In brief

The purpose of this study is to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis, to see if it can improve blood tests associated with inflammation (tissue damage). Pentoxifylline is approved by the US Food and Drug Administration (FDA) for treatment of circulation problems, but its use in this study is investigational, which means that the FDA has not approved it for the treatment of pancreatitis. However, the FDA has allowed the use of pentoxifylline in this research study.

Key facts

Study ID

NCT01292005

Run by

Mayo Clinic

People needed

28

Starts

2009-04-01

Expected to finish

2012-07-01

Last updated by the study team

2016-10-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Predicted Severe Acute Pancreatitis
• Enrollment within 72 hours of diagnosis
• Ability to give informed consent
• Age >17 years

You may not qualify if…

• Moderate or severe congestive heart failure
• History of seizure disorder or demyelinating disease
• Nursing mothers
• Pregnancy
• History of prior tuberculosis or risk factors for tuberculosis
• Evidence of immunosuppression (malignancy, chronic renal failure, chemotherapy within 60 days, ongoing steroid treatment*, and HIV)- (*the exception of prednisone use will be allowed to participate).
• Evidence of chronic pancreatitis from history and examination (however, "acute on chronic pancreatitis" diagnosis is allowed)
• Evidence of active or pending hemorrhage.
• Paralytic ileus with vomiting

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.