Conformal Partial Breast Irradiation With CyberKnife After Resection for Early Stage Breast Cancer

Completed · Not applicable

Conditions studied: Breast Cancer

In brief

The purpose of this study is to determine if it is feasible, safe, and effective to use Cyberknife radiotherapy to deliver partial breast radiotherapy after lumpectomy.Patients meeting eligibility criteria will be invited to participate. Adjuvant radiotherapy will be delivered using CyberKnife radiotherapy using twice daily sessions for five days for a total of ten sessions. Short-term and long-term toxicity will be assessed as well as Tumor control and site of failure (if any).

Key facts

Study ID

NCT01290835

Run by

Essentia Health

People needed

20

Starts

2010-06-01

Expected to finish

2025-08-01

Last updated by the study team

2025-08-15

Who can join

Age: 60 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of breast malignancy, stage T1
• Surgical treatment with lumpectomy
• age 60 or older
• resection margins negative by at least 2mm
• any grade
• ER positive
• unicentric
• invasive ductal
• pathologic free of nodal metastases (N0, i- or i+)
• Post-lumpectomy cavity to whole breast ratio must be less than or equal to 30%

You may not qualify if…

• Prior radiotherapy to the breast
• Neoadjuvant chemotherapy
• multicentric disease
• Pure DCIS histology
• Presence of extensive intraductal component
• Node positive disease (N1 or greater)

Where it is running

• Essentia Health SMDC Cancer Center — Duluth, Minnesota, United States

Full record on ClinicalTrials.gov

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