Use of a Loading Dose of Vancomycin in Pediatric Dosing

Stopped early · Not applicable

Conditions studied: Infection

In brief

Vancomycin is an antibiotic administered to children or adults for many types of infections. While it has been used to treat infections of children for more than 50 years we are still not completely certain about the best dose to use when starting treatment with this medication. This study is intended to evaluate whether giving a new higher dose of vancomycin for the first dose will help us get to the desired amount in the body more quickly then the usual first dose. Half of the patients would get the new higher dose and the other half of patients will get the typical first dose. Only the first dose is changed and all doses that follow are the same in both groups and are doses typically used for children.

Key facts

Study ID

NCT01290237

Run by

Boston Children's Hospital

People needed

59

Starts

2011-02-01

Expected to finish

2012-03-01

Last updated by the study team

2018-06-19

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Receiving care at Children's Hospital Boston
• Prescribed intravenous vancomycin by their physician

You may not qualify if…

• Weight above 67 kg
• Pre-existing renal dysfunction (creatinine clearance < 50 ml/min/1.73m2)
• Known hearing impairment
• Recent intravenous vancomycin treatment (within 7 days)
• Undergoing procedure with anticipated moderate-severe blood loss

Where it is running

• Children's Hospital Boston — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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