Immune Responses After Human Subject Challenge With Sand Fly Bites

Completed

Conditions studied: Healthy

In brief

Sand flies can carry the infection leishmaniasis (a parasite). The purpose of this study is to evaluate the human immune response to uninfected laboratory raised sand fly bites and select from the immune response to sand fly saliva, possible substances to use for a future vaccine to protect against the parasite leishmaniasis.

Key facts

Study ID

NCT01289977

Run by

Uniformed Services University of the Health Sciences

People needed

68

Starts

2010-10-01

Expected to finish

2016-04-15

Last updated by the study team

2018-02-19

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-50
• Plans to remain in DC area for at least one year
• willingness to participate in all study procedures
• general good health
• military health care beneficiary
• able to provide informed consent

You may not qualify if…

• Prior travel to geographic areas where leishmania transmitting sand flies are common
• positive antibody to sand fly saliva on screening blood test
• pregnancy
• elevated serum IgE
• history of chronic medical illness
• adult history of treatment requiring anemia
• large reactions to insect bites
• history of multiple vasovagal reactions to phlebotomy
• difficult venous access for phlebotomy
• Taking medications that could interfere with immune responses

Where it is running

• Walter Reed National Military Medical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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