Proteogenomic Biomarker Panels in a Serial Blood & Urine Monitoring Study of Kidney Transplant Recipients
Completed
Conditions studied: Kidney Transplant, Kidney Transplantation
In brief
There is a need to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had kidney transplant. Researchers will examine blood, urine, and tissue samples and try to identify genetic markers for certain conditions like rejection, response to therapy, and scarring of the kidney. By studying gene patterns, researchers hope to be able to diagnose these conditions earlier and improve kidney survival.
Key facts
- Study ID
- NCT01289717
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 307
- Starts
- 2011-03-01
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2017-08-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects undergoing primary or subsequent deceased-donor or living donor kidney transplantation
- Subject and/or parent guardian must be able to understand and provide informed consent
- Female subjects of childbearing potential must have a negative pregnancy test within 6 weeks of study entry.
You may not qualify if…
- Need for combined organ transplantation with an extra-renal organ and/or islet
- Recipient of previous non-renal solid organ and/or islet cell transplantation
- Infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV)
- Inability or unwillingness of a participant to give written informed consent or comply with study protocol
- Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.
Where it is running
- Mayo Clinic, Division of Nephrology — Phoenix, Arizona, United States
- The Scripps Research Institute, Scripps Center for Organ and Cell Transplantation, — La Jolla, California, United States
- Northwestern University, Feinberg School of Medicine, Division of Organ Transplantation — Chicago, Illinois, United States
- The Cleveland Clinic — Cleveland, Ohio, United States
- Medical University of South Carolina, Division of Transplant — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
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