Efficacy of Lanthanum Carbonate in Calciphylaxis

Completed · Phase 1

Conditions studied: Calciphylaxis

In brief

The research question and primary aim is to determine if lanthanum carbonate is effective in treating calciphylaxis by measurement of complete or partial remission of skin lesions. Secondary endpoints will be measured to determine if lanthanum carbonate can lower calcium-phosphorus product levels, intact PTH and mortality. Albumin levels will be measured as a marker of nutritional status and inflammation.

Key facts

Study ID

NCT01289626

Run by

University of Wisconsin, Madison

People needed

12

Starts

2011-02-01

Expected to finish

2013-05-01

Last updated by the study team

2014-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• i Participants will have signed a witnessed informed consent. ii Participants will be greater than or equal to 18 years of age iii Chronic renal failure receiving hemodialysis or peritoneal dialysis iv A diagnosis of calciphylaxis proven by skin biopsy or initial dermatology visit within the previous 5 year v Serum phosphorus > 4.5 mg/dL

You may not qualify if…

• i Participants are not able to understand or provide written informed consent ii The research team deems that the participant may not be able to follow the study protocol.
• iii Non-dependent HD patients receiving dialysis while in acute kidney injury; iv Pregnant dialysis patient v Active gastrointestinal obstruction or bleed vi Active inflammatory bowel disease vii Acute arteriovenous graft occlusion viii Known hypersensitivity to FOSRENOL®

Where it is running

• University of Wisconsin Hospitals — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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