Observational Study of Blood Pressure Measurements and Continuous Dialysis

Stopped early

Conditions studied: Kidney Failure, Respiratory Failure, Critical Illness, Shock

In brief

Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid removal is much more difficult. This study aims to determine whether changes in the blood pressure associated with breathing correlate with or predict intolerance to fluid responsiveness with continuous dialysis. We hypothesize that a measurement of changes in blood pressure with breathing called arterial pulse pressure variation may be able to predict the ability to remove fluid during continuous renal replacement therapy.

Key facts

Study ID

NCT01286506

Run by

University of Chicago

People needed

7

Starts

2011-02-01

Expected to finish

2015-12-01

Last updated by the study team

2016-08-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age > 17 years old
• CVVHD renal replacement therapy
• indwelling arterial line

You may not qualify if…

• age < 18 years old
• pregnancy
• temperature < 34°C
• severe mechanical ventilator dyssynchrony
• cardiac arrhythmias precluding automated PPV measurement by ICU monitors
• non-pulsatile cardiac flow
• open thoracic cavity

Where it is running

• The University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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