Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles

Completed · Not applicable

Conditions studied: Compare Pregnancy Rates Between FSH Stimulation and FSH and, GnRH Antagonist

In brief

Ovulation induction (OI) using gonadotropins is one of the most widely prescribed treatments of infertility. One common problem encountered while attempting OI using gonadotropins is premature ovulation. The purpose of this study is to examine the effect of a single injection of a medication, called ganirelix, to prevent premature ovulation. Patients will be divided into two groups. In the first group, gonadotropins will be used to stimulate the ovaries. In the second group gonadotropins will be used in addition to a single injection of ganirelix, a gonadotropin releasing hormone (GnRH) antagonist. Pregnancy rates will be compared between groups.

Key facts

Study ID

NCT01286051

Run by

Houston Fertility Institute

People needed

80

Starts

2011-01-01

Expected to finish

2012-09-01

Last updated by the study team

2013-03-20

Who can join

Age: 18 and older, up to 39. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Patients undergoing ovulation induction (OI) between ages 18 - 39 years.
• One or more of the following infertility diagnoses: ovulation dysfunction, mild male factor infertility (sperm concentration of 5- 20 million/ml, and/or sperm motility 10% - 40%) , absence teratospermia (i.e. strict morphology > 4%), unexplained infertility.
• Patent Fallopian tubes.
• Normal uterine structure (i.e. absence of mullerian anomalies)
• Ability to consent to the study.
• Patients should be Houston Fertility Institute patients

You may not qualify if…

• Exclusion criteria include:
• Age 39 or above
• Severe male factor (concentration < 10 million/ml or strict morphology < 4%)
• Obstructed Fallopian tubes on one or both sides
• Stage III or IV endometriosis
• Elevated FSH level (>10 IU/L)
• Low antral follicular count (< 4 antral follicles per ovary)
• Any other contraindication for ovulation induction
• Inability to consent to the study
• History of any prior failed OI/IUI cycle

Where it is running

• Houston Fertility Institute — Houston, Texas, United States

Full record on ClinicalTrials.gov

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