The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis

Completed · Not applicable

Conditions studied: Adult Growth Hormone Deficiency, Hypothalamic-pituitary Disorders

In brief

The purpose of this study is to find out if the Glucagon Stimulation Test (GST) is a reliable alternative to the Insulin Tolerance Test (ITT) for diagnosis of Growth Hormone Deficiency (GHD) and adrenal insufficiency. In some patients the accuracy of the GST for evaluation of adrenal insufficiency is compared to the adrenocorticotropin hormone (ACTH ) stimulation test.

Key facts

Study ID

NCT01282164

Run by

The Cleveland Clinic

People needed

43

Starts

2011-01-01

Expected to finish

2014-07-01

Last updated by the study team

2017-05-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 80 years of age
• male and female
• hypothalamic pituitary disorders (study subjects)
• history of regular, age appropriate menses (control subjects)
• male subjects with normal serum testosterone and follicle stimulating hormone (FSH) (control subjects)
• normal FSH in post-menopausal subjects (control subjects)
• normal thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin (control subjects)

You may not qualify if…

• unable to give consent
• pregnancy
• active acromegaly
• pheochromocytoma
• active Cushing's disease
• pituitary insult within past 6 weeks
• elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST)
• renal failure
• history of malignancy
• severe acute illness
• uncontrolled hypertension
• Diabetes mellitus (DM) type 1
• Hemoglobin (Hgb) A1c >9% in last 3 months in Type 2 DM
• severe coronary artery disease
• women <50 years of age with untreated hypogonadism
• men with untreated hypogonadism
• growth hormone treatment in the past 3 months

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Cleveland Clinic Endocrinology, Diabetes and Metabolism — Cleveland, Ohio, United States
• Oregon Health and Sciences University — Portland, Oregon, United States
• Allegheny Endocrinology Associates — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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