Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus

Completed

Conditions studied: Barrett's Esophagus

In brief

The purpose of this study is to determine the association between acid reflux and cell changes in Barrett's esophagus. Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal activation. Specific aim 2: To test the hypothesis that stromal fibroblast derived growth factors drive BE epithelial proliferation.

Key facts

Study ID

NCT01281618

Run by

Mayo Clinic

People needed

48

Starts

2008-10-01

Expected to finish

2011-06-01

Last updated by the study team

2013-05-06

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Prior histological demonstration of Barrett's esophagus that is endoscopically visible; length of visible segment >/= 1 cm
• Absence of dysplasia or LGD on biopsies within the past 5 years
• Ability to provide informed consent
• Age between 18 years and 90 years at study entry.

You may not qualify if…

• Eastern Cooperative Oncology Group performance status 3 or 4
• Inability to tolerate endoscopic procedures
• Pregnancy: Females of child-bearing age will be screened with pregnancy test.
• Prior esophageal surgery, or cancer

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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