Face Transplantation for Treatment of Severe Facial Deformity
Completed · Not applicable
Conditions studied: Severe Facial Deformity
In brief
Face transplantation surgery is the transfer of face tissue from a deceased human donor to a patient with a severe facial deformity. Face transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with severe facial injuries. The purpose of this study is to develop the best practices for facial transplantation that will improve the outcomes of future face transplant recipients.
Key facts
- Study ID
- NCT01281267
- Run by
- Brigham and Women's Hospital
- People needed
- 10
- Starts
- 2009-09-01
- Expected to finish
- 2019-11-12
- Last updated by the study team
- 2021-01-27
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18 and 60 years.
- Loss of a major part of the face, such as the nose or the lips, or at least 25% of the facial tissue.
- The facial defect cannot be restored with traditional reconstruction techniques.
- Signed written informed consent.
- Willing to complete psychological and social evaluations.
- Willing to take immunosuppressants - drugs that help prevent rejection of the transplant - for life.
- Willing to return for follow-up visits as determined by the treating physician and to comply with extensive post-transplant rehabilitation therapy.
- Willing to receive standard vaccinations prior to the transplant, such as influenza and hepatitis B.
You may not qualify if…
- Active malignancy.
- High risk of return of malignancy.
- History of persistent non-compliance.
- Findings of psychological evaluation that indicate inability to comply with physician's orders or mental instability.
- Any diagnosis that puts the subject at risk during the face transplant surgery.
- Absence of adequate donor sites for skin grafting in the event of transplant failure.
Where it is running
- Brigham & Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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