Anti-inflammatory Agents and Cholesterol Metabolism

Stopped early

Conditions studied: Osteoarthritis

In brief

We hypothesize that administration of anti-inflammatory medications such as celecoxib, naprosyn and diclofenac will cause changes in the blood plasma and white blood cells of patients such that they will be less able to efficiently process cholesterol.

Key facts

Study ID

NCT01279395

Run by

Winthrop University Hospital

People needed

3

Starts

2010-11-01

Expected to finish

2018-01-18

Last updated by the study team

2019-08-16

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 40-70, osteoarthritis, male or female

You may not qualify if…

• other known autoimmune or inflammatory rheumatic conditions, renal disease, current or recent (>1 month) corticosteroid or statin treatment, contraindications to medication (i.e. those taking oral anticoagulants, e.g. warfarin), those pregnant or trying to become pregnant or breastfeeding. Participants will not have consumed any medications containing aspirin or other NSAIDs for at least 2 weeks before the trial.

Where it is running

• Winthrop University Hospital — Mineola, New York, United States

Full record on ClinicalTrials.gov

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