Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Cardiac Allograft Vasculopathy, Heart Transplant Recipients

In brief

All people who have a heart transplant are at risk for developing cardiac allograft vasculopathy (CAV). CAV means narrowing of the heart transplant vessels, which is associated with poor heart transplant function. People who develop antibodies after transplant have a higher risk of developing CAV. Infections, high cholesterol, and rejection also increase the risk of developing CAV. People who develop CAV usually have to receive another transplant.

Key facts

Study ID

NCT01278745

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

362

Starts

2011-09-01

Expected to finish

2015-10-01

Last updated by the study team

2020-08-25

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cedars Sinai Heart Institute — Beverly Hills, California, United States
• Ronald Regan UCLA Medical Center — Los Angeles, California, United States
• Stanford University/Palo Alto VA — Palo Alto, California, United States
• University of California San Francisco — San Francisco, California, United States
• Stanford University — Stanford, California, United States
• Northwestern University — Chicago, Illinois, United States
• University of Maryland — Baltimore, Maryland, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Minneapolis Heart Institute — Minneapolis, Minnesota, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mount Sinai School of Medicine — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Drexel University College of Medicine — Philadelphia, Pennsylvania, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Medical City Dallas Hospital/CRSTI — Dallas, Texas, United States
• The Methodist Hospital — Houston, Texas, United States
• Intermountain Medical Center — Murray, Utah, United States
• University of Utah — Salt Lake City, Utah, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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