Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting

Completed · Phase 4 · Has a placebo group

Conditions studied: Cardiovascular Risk Factor, C.Medical Procedure; Vascular, Functional or Late, Electrolyte and Fluid Balance Conditions

In brief

The investigators hypothesize that 1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet activation, platelet aggregation, and clotting potential, b) increased fibrinolytic potential following fire fighting, c) no significant effect on endothelial function or arterial stiffness versus the placebo condition. 2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire fighting induced platelet activation, platelet aggregation, clotting potential, b) increased fibrinolytic potential, and c) increased endothelial function and decreased arterial stiffness in response to live fire fighting versus the placebo condition. 3. short-term fire fighting activity will result in: a) a reduction in arterial function (reduced endothelial function, increased augmentation index and an attenuated arterial stiffness response); b) a disruption in hemostasis that is characterized by an increase in platelet number and function, an increased coagulatory potential and altered fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic inflammation, monokine chemoattractant protein, and matrix metalloproteinases.

Key facts

Study ID

NCT01276691

Run by

University of Illinois at Urbana-Champaign

People needed

24

Starts

2011-02-01

Expected to finish

2012-12-01

Last updated by the study team

2020-07-21

Who can join

Age: 40 and older, up to 60. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male firefighters (career and volunteer), medically cleared by home fire department.
• Ages 40 - 60
• Completion of a yearly period medical evaluation based on NFPA 1582 within the past 12 months or an evaluation by an occupational medical group through this study.

You may not qualify if…

• Over 60 or under 40 years of age.
• Not a firefighter.
• Individuals at risk for developing gastrointestinal (GI) complications while on aspirin therapy due to a combination of the following: smoking; concurrent NSAID, steroid, Clopidogrel, or Warfarin therapy; history of upper GI complications; history of renal impairment; history of elevated serum creatinine; hypertension; and cardiac failure.
• Individuals with cases of allergy or asthma, intolerance, and recurrent vascular events.
• Individuals taking statins.
• Individuals who are currently taking aspiring regularly.

Where it is running

• Illinois Fire Service Institute — Champaign, Illinois, United States

Full record on ClinicalTrials.gov

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