Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis

Status unconfirmed

Conditions studied: Coronary Artery Disease

In brief

About 13 million people in the United States have coronary artery disease (CAD). It is the leading cause of death in both men and women. Coronary artery disease (CAD) occurs when the blood vessels that supply blood to the heart muscle (the coronary arteries) become hardened and narrowed. The arteries harden and narrow due to buildup of fatty and calcified material called plaque on their inner walls. The buildup of plaque is also called atherosclerosis. This is a process which starts early in life, but can be influenced by multiple factors. Several factors increase the risk of developing atherosclerosis. They include high blood pressure, smoking, diabetes, high cholesterol and being related to someone who had a heart attack or a stroke. The more risk factors you have, the greater the chance that you have severe atherosclerosis. Some of the risk factors cannot be modified, like age and family history of early heart disease. The influenceable factors include high blood pressure, high blood cholesterol, high blood sugar, cigarette smoking, overweight or obesity, and lack of physical activity. Nevertheless, there are patients without any above mentioned risk factors who develop atherosclerosis. In addition to that, there are also patients with several risk factors who do not develop severe coronary artery disease. According to research studies high blood levels of some substances in the blood (biochemical markers) as well as some genes in the DNA of our cells may be associated with an increased risk of developing CAD and faster progression of the disease. The purpose of this study is to find a correlation between certain blood markers and growth of the plaques, regardless of the presence of the classic risk factors for atherosclerosis. If we prove our hypothesis we will be one step closer to predicting the extent of atherosclerosis by performing certain blood tests.

Key facts

Study ID

NCT01276678

Run by

LifeBridge Health

People needed

1300

Starts

2010-06-01

Expected to finish

2014-12-01

Last updated by the study team

2013-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥18 years
• Subjects scheduled for coronary angiography
• Subjects who have undergone coronary angiography within 5 years

You may not qualify if…

• Female subjects who are pregnant
• Subjects who suffer currently from an acute infection
• Subjects, who have received an experimental drug or who gave a blood donation of ≥ 1 pint within 8 weeks prior to screening
• Subjects with any coagulation, bleeding or blood disorders
• Subjects who are undergoing treatment for neoplastic diseases
• Subjects with autoimmune disease or connective tissue disease
• Subjects with HIV or hepatitis C.
• Subjects with any abnormal laboratory value or physical finding that according to the investigator may interfere with the interpretation of the study results, be indicative of an underlying disease state, or compromise the safety of a potential subject

Where it is running

• Sinai Center for Thrombosis Research — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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