The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury

Completed · Not applicable

Conditions studied: Acute Kidney Failure

In brief

The primary objective is to safely determine if the investigators can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled the investigators will draw blood and urine for novel and standard biomarkers. The investigators are attempting to determine if these biomarkers can forecast the course of AKI (need for dialysis, death and renal recovery). The investigators seek to determine how well physicians caring for those with AKI can predict the clinical course compared to these novel biomarkers of AKI and if there is an association between clinical course and 3 year patient outcomes.

Key facts

Study ID

NCT01275729

Run by

University of Chicago

People needed

96

Starts

2010-12-01

Expected to finish

2022-06-01

Last updated by the study team

2023-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 yrs or older
• increase in serum creatinine of 0.3 mg/dl within 48 hours or an increase of greater than or equal to 150% from baseline or sustained oliguria (UOP < 0.5 cc/kg/hr for 6 hours with the last 48hours)
• written informed consent
• patients with an indwelling bladder catheter

You may not qualify if…

• Voluntary refusal
• Patients with advanced chronic kidney disease - as defined by a baseline glomerular filtration rate (GFR) < 30 ml/min (MDRD)
• history of renal transplant
• Pregnant patients
• Allergy / Sensitivity to Loop diuretics (furosemide)
• Pre-renal AKI
• defined by a Fractional Excretion of Sodium (FENa) of < 1% and no urinary casts
• under-resuscitated as per the treating clinical team
• active bleed
• Post renal AKI
• evidence of hydro-ureter
• clinical scenario wherein obstruction is considered a likely possibility

Where it is running

• University of California-San Francisco — San Francisco, California, United States
• George Washington University — Washington D.C., District of Columbia, United States
• University of Chicago — Chicago, Illinois, United States
• Johns Hopkins Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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