CARDIA Brain MRI Substudy
Completed
Conditions studied: Brain Aging, Obesity, Diabetes
In brief
Background: \- The Coronary Artery Risk Development in Young Adults (CARDIA) study is an investigation of cardiovascular risk factors among African-American and white young adults between 18 and 30 years of age, first recruited in 1985 86 from Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. The study has examined a wide variety of risk factors, including insulin resistance, obesity, and diabetes. Based on 20 years of followup, the data provide evidence of an increase in the prevalence of many cardiovascular risk factors, as well as other factors that may lead to brain disease. To further evaluate these changes, the CARDIA Year 25 Exam will include a brain imaging component to study brain structure and function in a subset of CARDIA participants. Objectives: \- To conduct brain magnetic resonance imaging as part of a 25-year followup study on participants in the original CARDIA study of heart disease risk factors in young adults. Eligibility: \- Existing CARDIA study participants in the Minneapolis, MN, and Oakland, CA regions. Design: * Participants will be screened with a full medical history and physical examination. - Participants will have an MRI scan at the 25-year followup examination for the CARDIA study. * No additional testing or treatment will be required for this protocol.
Key facts
- Study ID
- NCT01273311
- Run by
- National Institute on Aging (NIA)
- People needed
- 719
- Starts
- 2010-12-22
- Expected to finish
- 2014-02-18
- Last updated by the study team
- 2018-04-05
Who can join
Age: 35 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Participants with a known contraindication to an MRI examination will be excluded from the study (severe claustrophobia, pacemaker, defibrillator, neuro-stimulator, ferro-magnetic aneurysm clip or an unknown, 3T MR incompatible metal implant of any kind or any foreign metal objects in the body such as bullets, shrapnel, metal slivers, etc).
- Any female participant of childbearing age who has not tested negative on a pregnancy test prior to the scheduled MRI exam will also be excluded from participation in the Brain MRI Substudy.
Where it is running
- National Institute of Aging, Clinical Research Unit — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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