Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI
Completed · Phase 1 · Has a placebo group
Conditions studied: Spinal Cord Injury
In brief
The goal of the study is to examine the effects of repeated breathing episodes of mild intermittent hypoxia (reduced oxygen) training on hand strength and grasping ability following cervical spinal injury, and to determine whether these changes result in improved hand function. If so, such changes may indicate hypoxia-induced spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences), which could result in improvements in hand use for persons with spinal cord injury (SCI).
Key facts
- Study ID
- NCT01272336
- Run by
- Emory University
- People needed
- 53
- Starts
- 2010-12-01
- Expected to finish
- 2015-10-01
- Last updated by the study team
- 2016-01-26
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age 18 and 65 years
- medical clearance to participate
- lesion below the 5th cervical spinous process (C5) and above the first thoracic spinous process (T1) with non-progressive etiology
- classified as motor-incomplete injury greater than 12 months
- independent breathing
You may not qualify if…
- Concurrent severe medical illness (i.e., infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed decubiti, and history of cardiac or pulmonary complications)
- Pregnant women because of the unknown affects of acute intermittent hypoxia on pregnant women and fetus
- Concomitant acquired brain injury
- History of seizures, brain injury, and/or epilepsy
- Diagnosed with obstructive sleep apnea
- Undergoing concurrent physical therapy
- Any contraindications to EMG testing procedures (skin sensitivity)
- Any contraindications to passive movement of the limbs
- Score of < 24 on Mini-Mental Exam
Where it is running
- Emory Center for Rehabilitation Medicine — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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