Effect of Vitamin D Replacement on Insulin Sensitivity
Completed · Phase 1 · Has a placebo group
Conditions studied: Insulin Sensitivity
In brief
Healthy subjects with low Vitamin D levels will be randomly assigned to either Vitamin D replacement or placebo for a period of 8 weeks. Insulin sensitivity will be measured before and after the intervention, and the changes will be compared between the two groups. This will help us understand if Vitamin D replacement improves insulin sensitivity. Serum Retinol Binding Protein 4 levels will also be measured to see if changes in insulin sensitivity are mediated by RBP4.
Key facts
- Study ID
- NCT01268111
- Run by
- Texas Tech University Health Sciences Center
- People needed
- 12
- Starts
- 2011-01-01
- Expected to finish
- 2012-03-01
- Last updated by the study team
- 2015-06-08
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 1. Age 18-60 years 2. No known medical illnesses requiring pharmacotherapy 3. Not on any mineral or vitamin supplements in the last 3 months
You may not qualify if…
- 1. Subjects requiring prompt initiation of pharmacotherapy, such as those with incidentally discovered diabetes mellitus or hypertension.
- Previous administration of glucocorticoids, retinoic acid derivatives, or insulin sensitizers in the preceding 3 months.
- Bariatric surgery or liposuction 4. Unintentional weight loss >5% of the body weight in last 3 months 5. Chronic smokers (> 1 pk/d for 10 years) 6. Alcohol use > 2 drinks/day
Where it is running
- Texas Tech University Health Sciences Center — Odessa, Texas, United States
Full record on ClinicalTrials.gov
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