Role of Pregnancy Related Hormones in Lowering the Insulin Requirement in Pregnant Women With Type 1 Diabetes

Withdrawn before enrolling · Phase 1 · Has a placebo group

Conditions studied: Type 1 Diabetes

In brief

This is a randomized, double-masked, placebo-controlled, single-center study to evaluate stimulated C-peptide secretion after exogenous administration of mild immunosuppression and growth-promoting factors to women with preexisting T1DM who had a decline in insulin requirement or had detectable C-peptide during a previous pregnancy. Fifteen subjects will be enrolled and randomly assigned in a 2:1 ratio to either active treatment or placebo in a parallel group design. Participation for individual subjects will consist of an initial Screening Visit, a 2-week baseline period, a Baseline Visit, visits at week 2 and 4 of the treatment period, a visit at the end of the treatment period (week 6), and a follow-up visit 2 weeks after study treatment discontinuation. Subjects will receive either active treatment or matching placebo of estradiol 1 mg every 8 hours; medroxyprogesterone 2.5 mg every 24 hours; hydrocortisone 2.5 mg every morning, 1.25 mg every afternoon, and 1.25 mg at bedtime each night; and growth hormone 2 mg once a day).

Key facts

Study ID

NCT01265017

Run by

Sansum Diabetes Research Institute

People needed

0

Starts

2012-07-01

Expected to finish

2020-06-01

Last updated by the study team

2018-04-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female aged 18 years or older with T1DM and a documented history of at least one of the following:
• Decrease in insulin requirement with no other medically determined reason
• Detectable C-peptide
• Free of systemic corticosteroid use within 3 months before study entry.
• Stable weight (±10%)
• Stable diet and exercise
• Stable insulin requirement (<20% variability in insulin does in the 2 weeks prior to screening)Normal renal function as measured by an estimated glomerular filtration rate (simple MDRD)
• Negative pregnancy test and not planning to become pregnant during the study period. The subject must be willing to use an effective nonhormonal method of birth control during the study.
• Able to provide written informed consent.

You may not qualify if…

• Diagnosis of type 2 diabetes.
• Abnormal thyroid function (thyroid-stimulating hormone [TSH] and free thyroxine [FT4] test results) defined as TSH <0.4mIU/L or TSH>4.5mIU/L or Free T4 <0.6ng/dL or Free T4>1.6ng/dL.
• Abnormal renal function, as defined by serum creatinine greater than 1.2 mg/dL
• Any medical condition that, in the opinion of the investigator, yields the subject not suitable for study participation, including history of stroke, cancer, hypercoagulable problems, risk for deep vein thrombosis, and other unstable hormonal conditions, or Addison's disease or growth hormone deficiency.
• Currently treated with systemic steroids, hydrocortisone, growth hormone, or immunomodulatory medications
• Currently lactating.
• Pregnant within the last 9 months.
• Menopausal
• Taking hormonal therapy
• Known hypersensitivity to any of the medications used in this study or any component of the formulation.
• Known eating disorder
• History of phlebitis

Where it is running

• Sansum Diabetes Research Institute — Santa Barbara, California, United States

Full record on ClinicalTrials.gov

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