Non-cancer Pain and Cognitive Impairment: A Disabling Relationship

Stopped early · Phase 4

Conditions studied: Arthritis, Pain, Cognitive Impairment

In brief

To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity arthritis pain; and Describe the association of change in non-cancer pain self-report with an older adults functional status (BPI and WOMAC and brief physical performance measure) and to determine if cognitive status modifies this relationship.

Key facts

Study ID

NCT01264965

Run by

University of Chicago

People needed

25

Starts

2011-01-01

Expected to finish

2014-02-01

Last updated by the study team

2020-12-11

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age over 65
• Pain at least 3 months duration
• Pain greater in lower extremity than other anatomical site with ambulation
• Pain self-report of moderate intensity of higher on an average day
• Community-dwelling
• Ambulatory
• Physician states participants have decision-making capacity to enroll into the trial
• Participants with cognitive impairment have a reliable caregiver
• Inadequate pain relief from NSAIDS and/or acetaminophen in the past

You may not qualify if…

• Current cancer requiring chemotherapy
• History of addiction to opioids or other controlled substance
• Consumes more than 2 alcoholic drinks a day
• Severe balance disturbance
• Intra-articular steroid injection in the past 6 weeks

Where it is running

• University of Chicago Medical Center Outpatient Senior Health Center South Shore — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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